Publications

Books , Chapters, Editorials

Cellular interactions in the pituitary stem cell niche.

Willis TL, Lodge EJ, Andoniadou CL, Yianni V. Cell Mol Life Sci. 2022 Dec 1;79(12):612. doi: 10.1007/s00018-022-04612-8.

PMID: 36451046

Steroidogenic Factor 1 Regulates Transcription of the Inhibin B Coreceptor in Pituitary Gonadotrope Cells.

Lin YF, Schang G, Buddle ERS, Schultz H, Willis TL, Ruf-Zamojski F, Zamojski M, Mendelev N, Boehm U, Sealfon SC, Andoniadou CL, Bernard DJ. Endocrinology. 2022 Oct 11;163(11):bqac131. doi: 10.1210/endocr/bqac131.

PMID: 35957608

Single nucleus transcriptome and chromatin accessibility of postmortem human pituitaries reveal diverse stem cell regulatory mechanisms.

Zhang Z, Zamojski M, Smith GR, Willis TL, Yianni V, Mendelev N, Pincas H, Seenarine N, Amper MAS, Vasoya M, Cheng WS, Zaslavsky E, Nair VD, Turgeon JL, Bernard DJ, Troyanskaya OG, Andoniadou CL, Sealfon SC, Ruf-Zamojski F. Cell Rep. 2022 Mar 8;38(10):110467. doi: 10.1016/j.celrep.2022.110467. PMID: 35263594

Sexual dimorphism in COVID-19: potential clinical and public health implications.

Bechmann N, Barthel A, Schedl A, Herzig S, Varga Z, Gebhard C, Mayr M, Hantel C, Beuschlein F, Wolfrum C, Perakakis N, Poston L, Andoniadou CL, Siow R, Gainetdinov RR, Dotan A, Shoenfeld Y, Mingrone G, Bornstein SR. Lancet Diabetes Endocrinol. 2022 Mar;10(3):221-230. doi: 10.1016/S2213-8587(21)00346-6. Epub 2022 Feb 1.

PMID: 35114136

TGFBR3L is an inhibin B co-receptor that regulates female fertility.

Brûlé E, Wang Y, Li Y, Lin YF, Zhou X, Ongaro L, Alonso CAI, Buddle ERS, Schneyer AL, Byeon CH, Hinck CS, Mendelev N, Russell JP, Cowan M, Boehm U, Ruf-Zamojski F, Zamojski M, Andoniadou CL, Sealfon SC, Harrison CA, Walton KL, Hinck AP, Bernard DJ. Sci Adv. 2021 Dec 17;7(51):eabl4391. doi: 10.1126/sciadv.abl4391. Epub 2021 Dec 15.

PMID: 34910520

Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.

Goncalves J, Moog S, Morin A, Gentric G, Müller S, Morrell AP, Kluckova K, Stewart TJ, Andoniadou CL, Lussey-Lepoutre C, Bénit P, Thakker A, Vettore L, Roberts J, Rodriguez R, Mechta-Grigoriou F, Gimenez-Roqueplo AP, Letouzé E, Tennant DA, Favier J.Cancer Res. 2021 Jul 1;81(13):3480-3494. doi: 10.1158/0008-5472.CAN-20-2936. Epub 2021 Jun 14.

PMID: 34127497

Dynamic Expression of Imprinted Genes in the Developing and Postnatal Pituitary Gland.

Scagliotti V, Costa Fernandes Esse R, Willis TL, Howard M, Carrus I, Lodge E, Andoniadou CL, Charalambous M.Genes (Basel). 2021 Mar 30;12(4):509. doi: 10.3390/genes12040509.

PMID: 33808370

Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

Lopez JP, Brivio E, Santambrogio A, De Donno C, Kos A, Peters M, Rost N, Czamara D, Brückl TM, Roeh S, Pöhlmann ML, Engelhardt C, Ressle A, Stoffel R, Tontsch A, Villamizar JM, Reincke M, Riester A, Sbiera S, Fassnacht M, Mayberg HS, Craighead WE, Dunlop BW, Nemeroff CB, Schmidt MV, Binder EB, Theis FJ, Beuschlein F, Andoniadou CL, Chen A. Science Advances. 27 Jan 2021:Vol. 7, no. 5, eabe4497 doi: 10.1126/sciadv.abe4497

PMID: 33571131

Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells.

Russell JP, Lim X, Santambrogio A, Yianni V, Kemkem Y, Wang B, Fish M, Haston S, Grabek A, Hallang S, Lodge EJ, Patist AL, Schedl A, Mollard P, Nusse R, Andoniadou CL. Elife. 2021 Jan 5;10:e59142. doi: 10.7554/eLife.59142.

PMID: 33399538

Insulin and obesity transforms hypothalamic-pituitary-adrenal axis stemness and function in a hyperactive state.

Werdermann M, Berger I, Scriba LD, Santambrogio A, Schlinkert P, Brendel H, Morawietz H, Schedl A, Peitzsch M, King AJF, Andoniadou CL, Bornstein SR, Steenblock C. Mol Metab. 2020 Nov 3:101112. doi: 10.1016/j.molmet.2020.101112.

PMID: 33157254

Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.

Emily J Lodge, Paraskevi Xekouki, Tatiane S Silva, Cristiane Kochi, Carlos A Longui, Fabio R Faucz, Alice Santambrogio, James L Mills, Nathan Pankratz, John Lane, Dominika Sosnowska, Tina Hodgson, Amanda L Patist, Philippa Francis-West, Francoise Helmbacher, Constantine Stratakis, Cynthia L Andoniadou

JCI Insight 2020 Oct 27;5(23):134310.doi: 10.1172/jci.insight.134310.

PMID: 33108146

Cancer Stem Cells in Pheochromocytoma and Paraganglioma.

Scriba LD, Bornstein SR, Santambrogio A, Mueller G, Huebner A, Hauer J, Schedl A, Wielockx B, Eisenhofer G, Andoniadou CL, Steenblock C.

Front Endocrinol (Lausanne). 2020 Feb 25;11:79. doi: 10.3389/fendo.2020.00079. eCollection 2020. PMID: 32158431

Biological Behaviour of Craniopharyngiomas.

Martinez-Barbera JP, Andoniadou CL.

Neuroendocrinology. 2020 Mar 4. doi: 10.1159/000506904.

PMID: 32126562

Novel medications inducing adrenal insufficiency.

Bornstein SR, Bornstein TD, Andoniadou CL.

Nat Rev Endocrinol. 2019 Aug 8. doi: 10.1038/s41574-019-0248-9.

PMID:31395963

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.

Lodge EJ, Santambrogio A, Russell JP, Xekouki P, Jacques TS, Johnson RL, Thavaraj S, Bornstein SR, Andoniadou CL.

Elife. 2019 Mar 26;8. pii: e43996. doi: 10.7554/eLife.43996.

PMID:30912742

Elife Digest, Biomedical Picture of the Day

Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress.

Steenblock C, Rubin de Celis MF, Delgadillo Silva LF, Pawolski V, Brennand A, Werdermann M, Berger I, Santambrogio A, Peitzsch M, Andoniadou CL, Schally AV, Bornstein SR.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12997-13002. doi: 10.1073/pnas.1814072115. Epub 2018 Dec 4.

PMID:30514817

Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

Bornstein SR, Steenblock C, Chrousos GP, Schally AV, Beuschlein F, Kline G, Krone NP, Licinio J, Wong ML, Ullmann E, Ruiz-Babot G, Boehm BO, Behrens A, Brennand A, Santambrogio A, Berger I, Werdermann M, Sancho R, Linkermann A, Lenders JW, Eisenhofer G, Andoniadou CL.

Mol Psychiatry. 2019 Jan;24(1):2-9. doi: 10.1038/s41380-018-0244-9. Epub 2018 Sep 21. No abstract available.

PMID:30242231

Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ.

Xekouki P, Lodge EJ, Matschke J, Santambrogio A, Apps JR, Sharif A, Jacques TS, Aylwin S, Prevot V, Li R, Flitsch J, Bornstein SR, Theodoropoulou M, Andoniadou CL.

Endocr Relat Cancer. 2019 Jan 1;26(1):215-225. doi: 10.1530/ERC-18-0330.

PMID:30139767

Prognostic utility of HPV specific testing in addition to p16 immunohistochemistry in oropharyngeal squamous cell carcinoma.

Sathasivam HP, Santambrogio A, Andoniadou CL, Robinson M, Thavaraj S.

Ann Oncol. 2018 Oct 1;29(10):2144-2145. doi: 10.1093/annonc/mdy313. No abstract available.

PMID:30101315

Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.

Apps JR, Carreno G, Gonzalez-Meljem JM, Haston S, Guiho R, Cooper JE, Manshaei S, Jani N, Hölsken A, Pettorini B, Beynon RJ, Simpson DM, Fraser HC, Hong Y, Hallang S, Stone TJ, Virasami A, Donson AM, Jones D, Aquilina K, Spoudeas H, Joshi AR, Grundy R, Storer LCD, Korbonits M, Hilton DA, Tossell K, Thavaraj S, Ungless MA, Gil J, Buslei R, Hankinson T, Hargrave D, Goding C, Andoniadou CL, Brogan P, Jacques TS, Williams HJ, Martinez-Barbera JP.

Acta Neuropathol. 2018 May;135(5):757-777. doi: 10.1007/s00401-018-1830-2. Epub 2018 Mar 14.

PMID:29541918

Basic Research Advances on Pituitary Stem Cell Function and Regulation.

Russell JP, Lodge EJ, Andoniadou CL.

Neuroendocrinology. 2018;107(2):196-203. doi: 10.1159/000488393. Epub 2018 Mar 14. Review.

PMID:29539624

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

Gonzalez-Meljem JM, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Mousavy-Gharavy SN, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Martinez-Barbera JP.

Nat Commun. 2017 Nov 28;8(1):1819. doi: 10.1038/s41467-017-01992-5.

PMID:29180744

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis.

Tommiska J, Känsäkoski J, Skibsbye L, Vaaralahti K, Liu X, Lodge EJ, Tang C, Yuan L, Fagerholm R, Kanters JK, Lahermo P, Kaunisto M, Keski-Filppula R, Vuoristo S, Pulli K, Ebeling T, Valanne L, Sankila EM, Kivirikko S, Lääperi M, Casoni F, Giacobini P, Phan-Hug F, Buki T, Tena-Sempere M, Pitteloud N, Veijola R, Lipsanen-Nyman M, Kaunisto K, Mollard P, Andoniadou CL, Hirsch JA, Varjosalo M, Jespersen T, Raivio T.

Nat Commun. 2017 Nov 3;8(1):1289. doi: 10.1038/s41467-017-01429-z.

PMID:29097701

Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.

Carreno G, Apps J, Lodge EJ, Panousopoulos L, Haston S, Gonzalez-Meljem JM, Hahn H, Andoniadou CL, Martinez-Barbera JP.

Development. 2017 Aug 14. pii: dev.153387. doi: 10.1242/dev.153387.

PMID:28807898

MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma.

Haston S, Pozzi S, Carreno G, Manshei S, Panousopoulos L, Gonzalez-Meljem JM, Apps K, Virasami A, Thavaraj S, Gutteridge A, Forshew T, Marais R, Brandner S, Jacques T, Andoniadou CL, Martinez-Barbera JP.

Development. 2017 Jun 15;144(12):2141-2152. doi: 10.1242/dev.150490. Epub 2017 May 15.

PMID:28506993

Expression Analysis of the Hippo Cascade Indicates a Role in Pituitary Stem Cell Development.

Lodge EJ, Russell JP, Patist AL, Francis-West P and Andoniadou CL.

Front. Physiol. 2016 Mar 14 7:114. doi: 10.3389/fphys.2016.00114

The effects of stress on brain and adrenal stem cells.

de Celis MF, Bornstein SR, Androutsellis-Theotokis A, Andoniadou CL, Licinio J, Wong ML, Ehrhart-Bornstein M.

Mol Psychiatry. 2016 Jan 26. doi: 10.1038/mp.2015.230.

PMID: 26809844

STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System?

Nikolakopoulou P, Poser SW, Masjkur J, Fernandez Rubin de Celis M, Toutouna L, Andoniadou CL, McKay RD, Chrousos G, Ehrhart-Bornstein M, Bornstein SR, Androutsellis-Theotokis A.

Horm Metab Res. 2016 Jan 19.

PMID:26783739

Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.

Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S, Gualtieri A, Basu B, Koniordou M, Wu CI, Bancalari RE, Rahikkala E, Veijola R, Lopponen T, Graziola F, Turton J, Signore M, Mousavy Gharavy SN, Charolidi N, Sokol SY, Andoniadou CL, Wilson SW, Merrill BJ, Dattani MT, Martinez-Barbera JP.

Proc Natl Acad Sci U S A. 2016 Jan 13. pii: 201503346.

PMID:26764381

Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma.

Martinez-Barbera JP and Andoniadou CL.

Stem Cells. 2016 Jan 13. doi: 10.1002/stem.2267

PMID:26763580

Activated WNT signaling in postnatal SOX2-positive dental stem cells can drive odontoma formation.

Xavier GM, Patist AL, Healy C, Pagrut A, Carreno G, Sharpe PT, Martinez-Barbera JP, Thavaraj S, Cobourne MT, Andoniadou CL

Sci Rep. 2015 Sep 28;5:14479. doi: 10.1038/srep14479.

PMID:26411543

Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling.

Heavner WE, Andoniadou CL, Pevny LH.

Neural Dev. 2014 Dec 9;9(1):27.

PMID:25488119

The role of the Sonic Hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism.

Gregory LC, Gaston-Massuet C, Andoniadou CL, Carreno G, Webb EA, Kelberman D, McCabe MJ, Panagiotakopoulos L, Saldanha JW, Spoudeas HA, Torpiano J, Rossi M, Raine J, Canham N, Martinez-Barbera JP, Dattani MT.

Clin Endocrinol (Oxf). 2014 Oct 17. doi: 10.1111/cen.12637.

PMID:25327282

CHD7 maintains neural stem cell quiescence and prevents premature stem cell depletion in the adult hippocampus.

Jones KM, Sarić N, Russell JP, Andoniadou CL, Scambler PJ, Basson MA.

Stem Cells. 2014 Sep 2. doi: 10.1002/stem.1822.

PMID:25183173

Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.

Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, Dattani MT, Pevny LH, Martinez-Barbera JP.

Cell Stem Cell. 2013 Oct 3;13(4):433-45. doi: 10.1016/j.stem.2013.07.004.

PMID:24094324

Research Highlight in Nature Reviews Cancer

ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies.

Webb EA, AlMutair A, Kelberman D, Bacchelli C, Chanudet E, Lescai F, Andoniadou CL, Banyan A, Alsawaid A, Alrifai MT, Alahmesh MA, Balwi M, Mousavy-Gharavy SN, Lukovic B, Burke D, McCabe MJ, Kasia T, Kleta R, Stupka E, Beales PL, Thompson DA, Chong WK, Alkuraya FS, Martinez-Barbera JP, Sowden JC, Dattani MT.

Brain. 2013 Oct;136(Pt 10):3096-105. doi: 10.1093/brain/awt218. Epub 2013 Sep 10.

PMID:24022475

Developmental mechanisms directing early anterior forebrain specification in vertebrates.

Andoniadou CL, Martinez-Barbera JP.

Cell Mol Life Sci. 2013 Oct;70(20):3739-52. doi: 10.1007/s00018-013-1269-5. Epub 2013 Feb 9. Review.

PMID:23397132

SOX2 regulates the hypothalamic-pituitary axis at multiple levels.

Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH, Dattani MT, Martinez-Barbera JP.

J Clin Invest. 2012 Oct 1;122(10):3635-46. doi: 10.1172/JCI64311. Epub 2012 Sep 4.

PMID:22945632

Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma.

Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH, Dattani MT, Martinez-Barbera JP.

Acta Neuropathol. 2012 Aug;124(2):259-71. doi: 10.1007/s00401-012-0957-9. Epub 2012 Feb 18.

PMID:22349813

HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.

Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP.

Development. 2011 Nov;138(22):4931-42. doi: 10.1242/dev.066597. Epub 2011 Oct 17.

PMID:22007134

SOX2 haploinsufficiency is associated with slow progressing hypothalamo-pituitary tumours.

Alatzoglou KS, Andoniadou CL, Kelberman D, Buchanan CR, Crolla J, Arriazu MC, Roubicek M, Moncet D, Martinez-Barbera JP, Dattani MT.

Hum Mutat. 2011 Dec;32(12):1376-80. doi: 10.1002/humu.21606. Epub 2011 Oct 11.

PMID:21919124

Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.

Gaston-Massuet C, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS, Taketo MM, Le Tissier P, Dattani MT, Martinez-Barbera JP.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11482-7. doi: 10.1073/pnas.1101553108. Epub 2011 Jun 2.

PMID:21636786

Flexibility of neural stem cells.

Remboutsika E, Elkouris M, Iulianella A, Andoniadou CL, Poulou M, Mitsiadis TA, Trainor PA, Lovell-Badge R.

Front Physiol. 2011 Apr 11;2:16. doi: 10.3389/fphys.2011.00016. eCollection 2011.

PMID:21516249

Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism.

Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D, Dattani MT, Martinez-Barbera JP.

Dis Model Mech. 2008 Nov-Dec;1(4-5):241-54. doi: 10.1242/dmm.000711. Epub 2008 Nov 6.

PMID:19093031

Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.

Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JM, Martinez-Barbera JP.

Dev Biol. 2008 Dec 15;324(2):322-33. doi: 10.1016/j.ydbio.2008.08.008. Epub 2008 Aug 18.

PMID:18775421

DNMT1 interacts with the developmental transcriptional repressor HESX1.

Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M, Martinez-Barbera JP.

Biochim Biophys Acta. 2008 Jan;1783(1):131-43. Epub 2007 Sep 7.

PMID:17931718

Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.

Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M, Martinez-Barbera JP.

Development. 2007 Apr;134(8):1499-508. Epub 2007 Mar 14.

PMID:17360769

Books, Chapters, Editorials

Read our Editorial to the special issue of Seminars in Cell and Developmental Biology on Craniofacial Development.

New book out: Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma

Pituitary Stem Cells Chapter in Pfaff D, Christen Y, editors. Stem Cells in Neuroendocrinology. Cham (CH): Springer; 2016.

Meeting Report for the 15th Colloque Médecine et Recherche of the Fondation IPSEN in the Endocrinology Series: “Stem Cells in Neuroendocrinology”. December 2015